Carbapenems area class of antibiotics with a broad spectrum of antibacterial activity. Carbapenems are one of the antibiotics of last resort for many bacterial infections, such as Escherichia coli (E. coli) and Klebsiella pneumoniae. Although antibiotic-resistant bacteria has been an issue for years, the past 10 years have seen an increase in the frequency with which carbapenem-resistant Enterobacteriaceae (CRE) has been identified. Infections caused by CRE often have limited therapeutic options, and invasive CRE infections have been associated with mortality rates higher than 40%. Some of the bacteria included in this family are Escherichia coli, and the Enterobacter and Klebisella species.
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